The US Environmental Protection Agency
(EPA) Integrated Risk Information System (IRIS) program develops
toxicologic assessments of environmental contaminants. IRIS assessments
provide hazard identification and dose-response assessment information.
The information is then used in conjunction with exposure information to
characterize risks to public health and may be used in risk-based
decisionmaking, in regulatory actions, and for other risk-management
purposes. Since the middle 1990s, EPA has been in the process of
updating the IRIS assessment of inorganic arsenic. In response to a
congressional mandate for an independent review of the IRIS assessment
of inorganic arsenic, EPA requested that the National Research Council
convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic
is the report of the first phase of that study. This report evaluates
critical scientific
issues in assessing cancer and noncancer effects of oral exposure to
inorganic arsenic and offers recommendations on how the issues could be
addressed in EPA's IRIS assessment.
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